The Pishesha Lab

​Nanobodies (abbreviated VHH, variable heavy domain of heavy chain) are single-chain proteins derived from camelid species that possess antibody-like ability to recognize three-dimensional targets while remaining simple to manufacture and modify. We actively conduct alpaca immunization campaigns and screening efforts to identify new nanobodies that exhibit precise, targeted biological functions. Applying various protein engineering methods, we are expanding the range of applications of these nanobodies as building blocks of therapeutic agents, immune engineering modulators, and as innovative tools for biochemistry and immune imaging. 

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In particular, we are exploring the use of nanobody-based strategies to mute unwanted immune responses by fine-tuning where and when cells of the immune system receive anti-inflammatory cues. Our goal is to sustainably counteract the hyperactive immune niche present in various autoimmune diseases. To test the efficacy of our strategy, we use both preclinical mouse models of autoimmune diseases and samples derived from patients. As an immunological counterpoint, we are also investigating the use of our nanobodies as an efficacious vehicle for therapeutics and vaccines against viral and parasitic infections.